covid19

Hi, is there any metrics on how many business closed because of covid in Taiwan ? I was thinking something like an historical count of business closure since 2018 to today

<https://github.com/g0v/covid19-data-list/issues/14|#14 How many business closed because of covid in Taiwan ?>

log from <https://g0v-slack-archive.g0v.ronny.tw/index/channel/C1CHAA0QL/2021-08#ts-1627987383.0019|g0v slack #general-en> eric&gt; Hi, is there any metrics on how many business closed because of covid in Taiwan ? I was thinking something like an historical count of business closure since 2018 to today mrorz&gt;This may help It’s the statistics for survived / closed business count (and their capital size) within the selected month (earliest data dates back to the year 2011), by cities <https://serv.gcis.nat.gov.tw/StatisticQry/cmpy/StaticFunction3.jsp|https://serv.gcis.nat.gov.tw/StatisticQry/cmpy/StaticFunction3.jsp> Data in XLS format is available here <https://dmz26.moea.gov.tw/GA/common/Common.aspx?code=F&amp;no=3|https://dmz26.moea.gov.tw/GA/common/Common.aspx?code=F&amp;no=3> Number of dismissed businesses per month by district In the left drawer you also have breakdown of dismissed companies by industries <https://user-images.githubusercontent.com/8068193/128340566-b598d9ca-5d88-4bee-b1b4-ed5943422332.png|image> Hmm instead of companies, I think business registrations would be more accurate. Most restaurants and independent shops won’t have a company <https://dmz26.moea.gov.tw/GA/common/Common.aspx?code=F&amp;no=26|https://dmz26.moea.gov.tw/GA/common/Common.aspx?code=F&amp;no=26> eric&gt; With the closure data not much to see : <https://docs.google.com/spreadsheets/d/1M0z-5K44A-QL0WnWBXkIjPErsUicBhqBWMnYSkYrDQk/edit?usp=sharing|https://docs.google.com/spreadsheets/d/1M0z-5K44A-QL0WnWBXkIjPErsUicBhqBWMnYSkYrDQk/edit?usp=sharing>

twitter.com

COVID-19 Chinese Archive (@cov19zharc1) | Twitter

The latest Tweets from COVID-19 Chinese Archive (@cov19zharc1). The COVID-19 Chinese Archive serves as an index of online Chinese contents about #COVID19. Click <https://t.co/nFFX5qs32o>

Lulu Keng 2021-08-13 22:02:35

Twitter 比較容易搜尋到，現在 google 還查不到啊，不過直接打的話網址是：https://cov19zharc.net/

8 ❤️ 4 🚀 3

HackMD

疫苗接種事項 - HackMD

# 疫苗接種事項 ###### tags: `自己的東西` :::info 蒐集台灣CDC大致上目前可以接種的COVID-19疫苗接種意願書以及注意事項，有想到就會更新以下的資訊。 ::: ##

法蘭西，浮生若夢

Brandy Vaughan：一個良心發現而起底製藥業的女人

布蘭迪・沃恩（Brandy Vaughan）是一名反疫苗運動家，曾在默克藥廠擔任三年業務。她形容自己是 「一位...

願景工程

科技疫調 空白授權 恐遭濫權 | 願景工程

疫情讓政府採取更多新科技防疫措施，但民眾足跡的數據資料，是否遭不當使用，人權團體提出不少質疑，東吳大學法律研究所教授李念...

sites.google.com

Health

2021 7/28 我接到學校關切施打實驗性生物製劑的電話，得知教育部變相強制老師施打疫苗。跟友人分享這個訊息後，我開始陸續加入一些討論群組。 7/31 我想將彭奕竣中醫師的電子書內容分享到FB，竟然無法分享，這時候我才感覺到有問題了。原來網路言論審查是真的，無法接納這樣一個中醫師的不同看法，讓我開始在不同的群組分享我接觸到的訊息。Youtube也是。這個<https://rumble.com/vkwga6-dr.-dan-stock-862021-better-audio.html影片被下架> 如果還想知道更近一步訊息，歡迎加入討論群組。 彭

擷取.PNG

mrorz 2021-08-20 12:22:35

> 當初就要求打不就好了
當初還在做疫苗ㄛ

irvin 2021-08-20 13:25:24

要不要打疫苗是個人選擇，台灣到目前還沒有強迫非造冊的職業從業人員打疫苗，個人仍然可以選擇不去理會，並且承擔相關風險

Alex 2021-08-20 16:31:31

但是老師被要求沒有打疫苗就要提供陰性證明，不能不理會的。將來也許會有疫苗護照，不強迫你打，但是很多事情你不能做，我們來思考看看是否合理？

kingman 2021-08-20 17:00:44

很合理，學生不能打疫苗；就跟臥病在床的老人不能打，但是身邊所有的照護人員都必須要打

不打疫苗，就有潛在散播風險，高接觸的行業與行為被阻擋也是剛好而已

不想打，可以自己選擇不要打，這是當然的自由權力
但是風險請自己承擔，別人可以要求不一起承擔這個不打疫苗的風險
甚至我認為不打疫苗，感染了請不要去醫院，在家自己休養就好

kingman 2021-08-20 17:04:01

新疾病的認識、研究、理解，醫療手段的Try & Error...
照護人力、器材的不足與產線(學校)加班加點把資源補上的過程

irvin 2021-08-20 21:54:29

部長有說現階段不做疫苗護照，就是要尊重選擇不打的人的人權。目前各地主政者中，最積極在推動疫苗紀錄做為活動門檻的是柯市長。

irvin 2021-08-20 21:58:01

如果要堅持自己不想打疫苗的權利，記得要向北市國民黨議員充分表達你的意見。北市一直往健康碼的制度在發展。

irvin 2021-08-20 22:01:17

部長這兩天記者會多次說現階段不做疫苗護照，就是中央政府盡力堅持保障選擇不打疫苗的人的人權。

目前各地主政者中，最積極在推動疫苗紀錄做為出入行動門檻的是北市柯市長。

北市一直往健康碼的制度在發展。如果要堅持自己不想打疫苗的權利，記得要向北市國民黨議員充分表達你的意見。

> 柯文哲稱疫苗護照勢在必行
> 北市議員應曉薇要求，市府應儘速建構疫苗通行證，讓施打2劑疫苗的民眾可在餐廳內用。對此，台北市長柯文哲持肯定態度，表示疫苗護照勢在必行，否則無法管理，台北採用「一卡一通一付」的作法也在環南市場試驗成功。
> https://www.google.com/amp/s/www.chinatimes.com/amp/newspapers/20210728000445-260107

Alex 2021-08-21 18:07:13

感謝兩位的理性分析！

Alex 2021-08-21 18:10:07

其中提到「不打疫苗，就有潛在散播風險」，打了疫苗也會傳給別人，不知道大家有沒有接觸到這方面的訊息。

中時新聞網

柯文哲稱疫苗護照 勢在必行 - 地方新聞

全台降為二級警戒首日，雙北餐飲仍持續禁止內用，北市議員應曉薇要求，市府應儘速建構疫苗通行證，讓施打2劑疫苗的民眾可在餐廳內用。對此，台北市長柯文哲持肯定態度，表示疫苗護照勢在必行，否則無法管理，台北採

Centers for Disease Control and Prevention

Coronavirus Disease 2019 (COVID-19)

CDC provides credible COVID-19 health information to the U.S.

Centers for Disease Control and Prevention

Coronavirus Disease 2019 (COVID-19)

CDC provides credible COVID-19 health information to the U.S.

cdc.gov

CDC Library: COVID-19 Science Updates

Stephen B. Thacker CDC Library is the CDC's hub for information, education, innovation and collaboration.

Centers for Disease Control and Prevention

Outbreak of SARS-CoV-2 Infections, including COVID-19 ...

This report describes COVID-19 outbreaks associated with ...

acechen 2021-08-24 00:09:42

你真的有點進去看嗎？哪裡可以推論「打過疫苗不一定比沒打疫苗更不容易受感染」？

acechen 2021-08-24 00:12:33

結論第一句就說了："First, data from this report are insufficient to draw conclusions about the effectiveness of COVID-19 vaccines against SARS-CoV-2, including the Delta variant, during this outbreak. As population-level vaccination coverage increases, vaccinated persons are likely to represent a larger proportion of COVID-19 cases."

Alex 2021-08-24 09:35:57

所以由此只能得知，接種疫苗者仍會染疫，但無法得到與未完全接種者之可能性的比較。謝謝acechen

kingman 2021-08-24 11:51:21

我不知道你如何解讀這段話的，我英文不好，所以無法直接閱讀英文，也許Google翻譯會有誤差

但是我用Google翻譯的解讀是
因為疫苗覆蓋率高，所以染疫的人數會有一定數量的完整疫苗接種者。
高疫苗覆蓋率的情況無法做疫苗與無疫苗的保護力比較...

印象也是因為這種情況，以及道德倫理顧慮，所以有在討論後出疫苗的免疫橋接

Alex 2021-08-24 17:01:45

差不多喔

kingman 2021-08-24 18:05:29

疫苗本身的保護力，在EUA的條件美國、以及台灣現在這三支進口的，都已經有做過保護力的臨床實驗了，只是面對的是原始武漢病毒株
這篇說的是現在三支疫苗面對印度Delta株，美國現況無法得出保護力的有效結論。

但是chsiao1981說的康復力，以及重症、死亡率，都還是有很明顯差異(與去年大爆發的時期比較)

新聞有提到美國目前染疫住院的，大多都是沒打過疫苗的人 (也是因為各種信仰、政治因素等...)

Alex 2021-08-25 11:28:33

但是也有接種疫苗者攜帶的病毒量遠超過未接種者的研究，不知道有接觸到相關資訊嗎？

kingman 2021-08-25 12:50:04

機率、活性

AP NEWS

US regulators give full approval to Pfizer COVID-19 vaccine

WASHINGTON (AP) — The U.S. gave full approval to Pfizer's COVID-19 vaccine Monday, a milestone that could lift public confidence in the shots and spur more companies, universities and local governments to make vaccinations mandatory.

medRxiv

Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine-breakthrough infections: a multi-center cohort study

Objectives Highly effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed but variants of concerns (VOCs) with mutations in the spike protein are worrisome, especially B.1.617.2 (Delta) which has rapidly spread across the world. We aim to study if vaccination alters virological and serological kinetics in breakthrough infections. Methods We conducted a multi-centre retrospective cohort study of patients in Singapore who had received a licensed mRNA vaccine and been admitted to hospital with B.1.617.2 SARS-CoV-2 infection. We compared the clinical features, virological and serological kinetics (anti-nucleocapsid, anti-spike and surrogate virus neutralization titres) between fully vaccinated and unvaccinated individuals. Results Of 218 individuals with B.1.617.2 infection, 84 had received a mRNA vaccine of which 71 were fully vaccinated, 130 were unvaccinated and 4 received a non-mRNA. Despite significantly older age in the vaccine breakthrough group, the odds of severe COVID-19 requiring oxygen supplementation was significantly lower following vaccination (adjusted odds ratio 0.07 95%CI: 0.015-0.335, p=0.001). PCR cycle threshold (Ct) values were similar between both vaccinated and unvaccinated groups at diagnosis, but viral loads decreased faster in vaccinated individuals. Early, robust boosting of anti-spike protein antibodies was observed in vaccinated patients, however, these titers were significantly lower against B.1.617.2 as compared with the wildtype vaccine strain. Conclusion The mRNA vaccines are highly effective at preventing symptomatic and severe COVID-19 associated with B.1.617.2 infection. Vaccination is associated with faster decline in viral RNA load and a robust serological response. Vaccination remains a key strategy for control of COVID-19 pandemic. ### Competing Interest Statement BEY reports personal fees from Roche and Sanofi, outside the submitted work. All other authors declare no competing interests. ### Funding Statement This study was funded by grants from the Singapore National Medical Research Council (COVID19RF-001, COVID19RF-008). The funders had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Written informed consent was obtained from study participants of the multi-centre study approved by National Healthcare Group Domain Specific Review Board (NHG-DSRB) (Study Reference 2012/00917). Informed consent for retrospective data collection at National Centre for Infectious Diseases (NCID) was waived (NHG-DSRB reference number 2020/01122). All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as <http://ClinicalTrials.gov|ClinicalTrials.gov>. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

Alex 2021-08-24 09:40:58

感謝chhsiao1981釋疑

Rumble

20210722MinYa與教師群討論會

新冠病毒的由來, 新冠疾病的病程, 病毒如何感染? 棘蛋白的危險性, AZ, Pfizer, Moderna疫苗作用原理的認識。 目前這三支疫苗真的能保護不受病毒感染嗎?

irvin 2021-08-25 17:40:17

你可以打個逐字稿或者至少摘錄重點出來
不然要別人幫你看兩小時，摘要後再去查證，不太合理

Guo-Jim 2021-08-25 17:46:27

可以去 cofacts 資料庫裡找找？ cc @bil @mrorz

Guo-Jim 2021-08-25 17:47:28

剛剛沒看到你在 cofacts 找過了😅

irvin 2021-08-25 17:53:13

甚至更好的事摘要重點之後自己先查證，把查到的資料也附上，再請問其他人幫你查那些你查不到的部分。

Guo-Jim 2021-08-25 17:55:18

你可以把影片裡聽到的東西傳到這個留言串，聽到一個就傳一個，不需要整個整理完再傳~之類的

Alex 2021-08-25 23:08:07

@guo-jim 我查詢「https://rumble.com/vkbrn7-20210722minya.html」及「*MinYa與教師群討論會*」，你確定我沒找？

毓球錢理路 2021-08-26 08:40:15

還有人不知道冠狀病毒從武漢實驗室出來的?

NaturalNews.com

Bombshell: Bill Gates partnered with CCP group to conduct coronavirus gain-of-function research

For the past five years, the Chinese Communist Party (CCP) via the National Natural Science Foundation (NSFC) of China has maintained a partnership with the Bill &amp; Melinda Gates Foundation [...]

Natural News

Natural News (formerly NewsTarget, which is now a separate sister site) is a far-right, anti-vaccination conspiracy theory and fake news website known for promoting alternative medicine, pseudoscience, and far-right extremism.The site's founder, Michael Allen "Mike" Adams, gained attention after posting a blog entry implying a call for violence against proponents of GMO foods, and then allegedly creating another website with a list of names of alleged supporters. He has been accused of using "pseudoscience to sell his lies". Adams has described vaccines as "medical child abuse".The website sells various dietary supplements, promotes alternative medicine and climate change denial, makes tendentious nutrition and health claims, disseminates fake news, and espouses various conspiracy theories and pro-Donald Trump propaganda. These conspiracy theories include chemophobic claims about the purported dangers of "chemtrails", fluoridated drinking water, anti-perspirants, laundry detergent, monosodium glutamate, aspartame, and vaccines. It has also spread conspiracy theories about the Zika virus allegedly being spread by genetically modified mosquitoes and purported adverse effects of genetically modified crops, as well as the farming practices associated with and foods derived from <http://them.As|them.As> of 2014, Natural News had approximately 7 million unique visitors per <http://month.In|month.In> May 2020, Facebook banned Natural News content from its platform after discovering that the site was boosting its popularity using content farms in North Macedonia and the Philippines, a form of spamming. Natural News bypassed the ban by republishing its content on a large number of topic-specific domain names, including trump.news, extinction.news, mind.control.news, and veggie.news. The Institute for Strategic Dialogue found 496 domain names associated with Natural News as of June 2020.

bioRxiv

SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome

Prolonged SARS-CoV-2 RNA shedding and recurrence of PCR-positive tests have been widely reported in patients after recovery, yet these patients most commonly are non-infectious[1][1]–[14][2]. Here we investigated the possibility that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome and that transcription of the integrated sequences might account for PCR-positive tests. In support of this hypothesis, we found chimeric transcripts consisting of viral fused to cellular sequences in published data sets of SARS-CoV-2 infected cultured cells and primary cells of patients, consistent with the transcription of viral sequences integrated into the genome. To experimentally corroborate the possibility of viral retro-integration, we describe evidence that SARS-CoV-2 RNAs can be reverse transcribed in human cells by reverse transcriptase (RT) from LINE-1 elements or by HIV-1 RT, and that these DNA sequences can be integrated into the cell genome and subsequently be transcribed. Human endogenous LINE-1 expression was induced upon SARS-CoV-2 infection or by cytokine exposure in cultured cells, suggesting a molecular mechanism for SARS-CoV-2 retro-integration in patients. This novel feature of SARS-CoV-2 infection may explain why patients can continue to produce viral RNA after recovery and suggests a new aspect of RNA virus replication. ### Competing Interest Statement The authors have declared no competing interest. [1]: #ref-1 [2]: #ref-14

端傳媒 Initium Media

【限額免費讀】專訪「疫苗猶豫」專家官晨怡：我們必須先理解人們不願打疫苗的原因｜端傳媒 Initium Media

面對疫苗猶豫（vaccine hesitancy），信任感的建立和「科學」一樣重要。

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mikechen 2021-08-26 20:58:11

Observational comparisons can easily draw incorrect conclusions when not controlling for factors such as:
1. *reporting period* (高端 ~3 days vs. AZ/Moderna > 3 months)
2. *age* (e.g. for AZ/Moderna: reported death rate for people >65 years old is 25 times higher than people <50)
3. *occupational and behavioral risks*
4. *pre-existing health conditions* (e.g. 第九類 skews towards AZ/Moderna)
If we only correct for age, and only look at people under 50 years old: 高端 has a reported death rate of 133-200% (in 3 days) vs. AZ/Moderna (over 3 months)

• 高端 = 3 deaths in 3 days / estimated 20-30萬 shots for people under 50 (第一輪高端預約為 36-65歲）
• AZ/Moderna = 30 deaths in 3 months / 400萬 shots (source)
That being said, there’s too short of reporting time and too little data at the moment.

chhsiao1981 2021-08-26 21:04:39

目前所發生的“死亡案例“～
都只能說是在接種後發生的情形～
這跟“某個人吃完飯以後發生意外“是一樣的描述～

並不能直接認定這些死亡案例都是因為接種疫苗以後導致的～

https://www.youtube.com/watch?v=I3ucQJNTNTc

chhsiao1981 2021-08-26 21:06:06

@profmikechen

mikechen 2021-08-26 21:10:39

None of the 3 + 30 reported deaths (or ~99.9% of all reported adverse events) have been confirmed to be associated with vaccination.

I’m only using it illustrate that the conclusion “不良反應的比例真的有明顯比 AZ / 莫德納的情形低很多” is not scientifically valid without correcting for (at least) the factors I mentioned.

chhsiao1981 2021-08-26 21:13:08

@profmikechen

釋昭慧那篇的 report 是沒有考慮到 age 這些 confounders～

kingman 2021-08-26 21:17:51

剛剛林氏壁也是說要用年齡區間下去比，還要排除背景值的其他不相關數據 ex. 意外傷害等...

mikechen 2021-09-08 16:47:34

Now that there has been 2 weeks of reported data on Medigen, let’s update the death rate stats:

*Summary*: for people <50yrs old, 高端 currently has a _reported death rate_ that is *213%* of AZ/Moderna, even with a much shorter reporting window (16 days vs. ~3 months).

• 高端 = 8 deaths in _16 days_ of reporting / estimated 50萬 shots for people <50yrs out of a total of 68萬 shots (source)
• AZ/Moderna = 30 deaths in ~_3 months_ of reporting / 400萬 shots (source)
Note: CDC has removed age-stratified stats since 8/25, and has stopped reporting adverse events as PDF since 8/19 prior to Medigen that started on 8/23.

irvin 2021-09-08 16:55:18

上圖中默德納 6/8~9/7 是153，上面你的文字統計是 30 in ~3月，兩個數字該怎麼對？

chhsiao1981 2021-09-08 21:08:52

@profmikechen

一直都是有提到打完疫苗以後死亡並不代表著打疫苗會造成死亡～

這些人也都是在死亡之前吃過晚餐～

目前大家的共識是這些到目前為止都只能算是背景值(background noise)～
並不能說明哪個疫苗比較容易導致死亡～

並不會因為使用英文就會資訊比較正確～